The endocannabinoid system (ECS) is the most extensive biological receptor system in the body. The endocannabinoids and the receptors they bind to are found throughout the body, from the nervous system and brain to vital organs.
The
ECS works to keep bodily functions, such as sleep, inflammation, mood, and pain, balanced (in
homeostasis). For example, when you are going through high-stress situations in life, your body releases cortisol, which is a stress hormone. To counter the effect of this stress hormone and ensure homeostasis, the body releases endocannabinoids to induce relaxation.
The ECS operates on a lock-and-key model. The cannabinoids are the keys, while the receptors are the locks. Whenever a key and lock fit, there is a physiological effect on the body.
The endocannabinoid responsible for runners' high is called anandamide, which is the key in this process. Two main receptors are associated with the blissful state during exercise, CB1 and CB2, which are the locks.
CB1 receptors regulate appetite, memory, and pain. They are found in the brain and spinal column. CB2 is found within the immune system and controls inflammation.
In the long run, the cannabinoid anandamide is released into the bloodstream and into the brain, where it finds the CB1 and CB2 receptors, and the lock and key system occurs. Suddenly there is less inflammation and no pain, and you have the endurance to run a 5k.
There are actually two types of cannabinoids found in nature that can activate the endocannabinoid system and create the runner’s high experience: endocannabinoids, which naturally occur in the body, and phytocannabinoids, which are found in plants. THC and CBD are two well-known examples of cannabinoids that come from plants, specifically hemp and marijuana.
These phytocannabinoids are similar in structure and behavior to the endocannabinoids. They are keys that fit perfectly into the CB1 and CB2 locks, causing that same feeling of euphoria when consumed. They may even improve muscle recovery after an intense workout.
Why the Runner’s High Is More Than Just a Feeling