Reverse tolerance, also known as sensitization, is a phenomenon where someone becomes more sensitive to the effects of a substance over time — even if they continue with the same amount or even less than what they originally started with.
In some instances (like with kava), this can actually mean that on the first, second, or even third attempt, people don’t feel the expected effects at all. Only with prolonged exposure do effects gradually develop in the body.
Reverse Tolerance vs. Tolerance: What's the Difference?
It may be easier to understand reverse tolerance by considering our conventional understanding of tolerance. Usually, tolerance refers to weakening effects over time. The more frequently we consume something, the less we feel the impact.
Caffeine is a prime example (and
cannabis is another). The first time you have a cup of coffee, the effects are profound. You'll immediately feel a sensational clarity, energy, and stimulation that's helped spawn a $100 billion industry.
Yet, over time, you'll likely reach for a second or third cup of coffee throughout the day just to feel the same initial effects. This is because you've slowly built up a resistance, or a tolerance, to these effects.
As the name suggests, reverse tolerance is the exact opposite of traditional tolerance. Over time, you'll find you need less and less to get the same payoff.
Reverse tolerance is also experienced among those who try something for the very first time. They may report feeling nothing instead of the immediate effects they were expecting.
In most cases of reverse tolerance, including kava, all it takes is perseverance. Over the course of a few days or even a week of daily enjoyment, the effects will clarify and become much more noticeable. Then, as kava-lovers report, they find their bodies respond faster to the effects. In some cases, people may even reduce the serving size for the same impact.
Reverse Tolerance and Kava