THC vs. CBD: What’s the Difference?

If you've heard of cannabis before, it's likely been about its two most well-known compounds: CBD and THC. While they share similarities in molecular makeup, their differences are significant, especially for newcomers to the cannabis experience.

To put these differences in a nutshell, THC is psychoactive whereas CBD is non-psychoactive. But this is a serious oversimplification. Before exploring the world of cannabis for yourself, you'll want to take a few minutes to understand what THC and CBD are, their legality, and how each affects the body.

Both CBD and THC produce their effects via interactions with the endocannabinoid system, or ECS. The ECS is a biological network of receptors and chemical messengers that manage everything from pain perception to mood fluctuations to the inflammatory response. 

It turns out that it's not just our own chemical messengers (called endocannabinoids) that work with this system. Scientists discovered that cannabis-derived cannabinoids also have an incredible ability to interact with the ECS due to their molecular structures. 

Yet, each cannabinoid operates in a unique way, which is why there are such differences between the effects of CBD vs. THC.

Let's first look at THC, and the related THC compounds like THCP, Delta-8-THC, and others. THC compounds are the only known cannabinoids that connect directly to a cannabinoid receptor called CB1. Although CB1 receptors exist throughout your body, they are highly concentrated in your brain. 

Why does THC bind to CB1? Well, THC happens to be structurally similar to anandamide, aka the “bliss molecule.” Anandamide is a natural endocannabinoid produced by the ECS. Like a hand fitting into a glove, THC molecules fit into CB1, which leads to the powerful effects THC is known for: euphoria, altered senses, mood uplift, and more.

Depending on the type of THC, the binding affinity of the molecule to the CB1 receptor will vary and therefore these effects will be felt to a lesser or greater degree. For example, THC-p has a stronger binding affinity than Delta-9 THC, but Delta-9 THC has a greater binding affinity than Delta-8.

Cannabidiol is the yang to THC's yin. Instead of fitting into a specific receptor, it works behind the scenes. For example, it actually stops the breakdown of anandamide. Thus, CBD boosts their impact on both the CB1 and CB2 receptors by keeping endocannabinoids like anandamide active longer.

CBD also works on a slightly different site of the CB1 receptor, changing how other compounds like THC interact with it. This can reduce the possibility of unpleasant side effects from THC. 

But other than these indirect effects, CBD doesn't develop into any truly powerful sensations. Instead, it's mellow and offers a mild, calm experience without any highs or lows.

With so many cannabinoids and so many different formats, where do you even begin? What cannabinoid should you start with? Should you try a gummy, flower, or something else?

Ultimately, if you've never dabbled with any hemp-derived cannabinoids, your first choice boils down to deciding between CBD vs. THC. Remember, CBD leads to mild, mellow relaxation without any psychoactive effects, while any THC (THCP, delta-8, delta-9, and the like) will lead to a range of mind-focused sensations. If you want to experience THC but are worried about the intensity, you can also try a balanced product with a 1:1 THC to CBD ratio.

Whether or not you care about the differences between THC and CBD, the golden rule with anything new is to start with a small amount and increase slowly. This is especially true for any type of THC products because they do trigger more noticeable sensations than CBD. 

If you are unfamiliar with THC, always start with the lowest recommended serving size, and don't go back for more until at least three or four hours later.

Finally, the product type will also impact the kind of experience you can expect. When you inhale cannabis, the effects come on quickly but don't linger for more than a few hours, while edibles can take a few hours to kick in, and the effects can last all day. Check your schedule, and choose accordingly.

As you familiarize yourself with THC and CBD, you begin to understand their unique properties. With a slow and steady approach, you'll start to find out what it's like to sink into the euphoric glow of THC and the mellow vibes of CBD.

But we think cannabinoids are always better together, so why not explore both for a balanced and well-rounded experience tailored just for you? Experience the full spectrum of benefits with our Select Spectrum Gummies with a 2:1 or 1:1 ratio of THC to CBD.

Until next time, mind your mind.

FDA Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure, or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your healthcare professional about potential interactions or other possible complications before using any product. The Federal Food, Drug, and Cosmetic Act requires this notice.