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THC vs. CBD: What’s the Difference?

THC vs. CBD: What’s the Difference?

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If you've heard of cannabis before, it's likely been about its two most well-known compounds: CBD and THC. While they share similarities in molecular makeup, their differences are significant, especially for newcomers to the cannabis experience.

To put these differences in a nutshell, THC is psychoactive whereas CBD is non-psychoactive. But this is a serious oversimplification. Before exploring the world of cannabis for yourself, you'll want to take a few minutes to understand what THC and CBD are, their legality, and how each affects the body.

Understanding Cannabinoids: THC vs. CBD

cannabis bud with trichomes

There are many ways of breaking down cannabis. There are strains (which fall in an indica, sativa, or hybrid category) and then there's the "type" (hemp vs. marijuana). The plant in general produces over 100 different cannabinoids with each variety of cannabis possessing a distinct cannabinoid profile. This unique combination of compounds determines the effects you get, from energetic and social to sleepy and soothing. 

Regardless of the strain or type, however, the two main cannabinoids you’ll find in cannabis plants are delta-9 tetrahydrocannabinol (also known as THC) and cannabidiol (CBD). It’s important to recognize the differences between these common compounds, so let’s begin with basic definitions. 

What Is THC?

Delta-9 THC is the primary psychoactive compound found in cannabis. It is perhaps the most famous cannabinoid because it offers most of the euphoric, mind-focused effects we associate with this plant.

It's usually the predominant cannabinoid in marijuana, but delta-9 THC is also derived from hemp, which is simply cannabis containing less than 0.3% of THC. 

What Is CBD?

CBD is a non-psychoactive, naturally occurring compound in cannabis. Since hemp can only contain a Delta-9 THC concentration of 0.3% or less, CBD is the most prolific cannabinoid produced by the hemp plant, although you'll also find trace amounts in marijuana. 

Unlike THC, CBD does not cause any altered state of mind. It's calming and soothing but will not trigger any of the intense sensations you might expect from THC. 

As a reminder, the federal government classifies any cannabis products that contain over 0.3 percent THC as marijuana, while anything under 0.3 percent THC is legal and classified as hemp.

Effects of CBD vs. THC and the Endocannabinoid System

woman holding a glass of buds


Both CBD and THC produce their effects via interactions with the endocannabinoid system, or ECS. The ECS is a biological network of receptors and chemical messengers that manage everything from pain perception to mood fluctuations to the inflammatory response. 

It turns out that it's not just our own chemical messengers (called endocannabinoids) that work with this system. Scientists discovered that cannabis-derived cannabinoids also have an incredible ability to interact with the ECS due to their molecular structures. 

Yet, each cannabinoid operates in a unique way, which is why there are such differences between the effects of CBD vs. THC.

Effects of THC

Let's first look at THC, and the related THC compounds like THCP, Delta-8-THC, and others. THC compounds are the only known cannabinoids that connect directly to a cannabinoid receptor called CB1. Although CB1 receptors exist throughout your body, they are highly concentrated in your brain

Why does THC bind to CB1? Well, THC happens to be structurally similar to anandamide, aka the “bliss molecule.” Anandamide is a natural endocannabinoid produced by the ECS. Like a hand fitting into a glove, THC molecules fit into CB1, which leads to the powerful effects THC is known for: euphoria, altered senses, mood uplift, and more.

Depending on the type of THC, the binding affinity of the molecule to the CB1 receptor will vary and therefore these effects will be felt to a lesser or greater degree. For example, THC-p has a stronger binding affinity than Delta-9 THC, but Delta-9 THC has a greater binding affinity than Delta-8.

Effects of CBD

Cannabidiol is the yang to THC's yin. Instead of fitting into a specific receptor, it works behind the scenes. For example, it actually stops the breakdown of anandamide. Thus, CBD boosts their impact on both the CB1 and CB2 receptors by keeping endocannabinoids like anandamide active longer.

CBD also works on a slightly different site of the CB1 receptor, changing how other compounds like THC interact with it. This can reduce the possibility of unpleasant side effects from THC. 

But other than these indirect effects, CBD doesn't develop into any truly powerful sensations. Instead, it's mellow and offers a mild, calm experience without any highs or lows.

The Benefits of THC and CBD

woman smoking a blunt or joint of marijuana

If you've done any online research, you'll know there are many claims about THC and CBD's health benefits. The truth is that more advanced clinical studies are needed to substantiate these compounds' purported therapeutic effects and health implications.

That isn't to say there hasn't been any research at all. Significant preliminary work has been done on both CBD and THC, giving us a general idea of what the future might hold for cannabinoids in medicine.

Research into CBD

Currently, the only Food and Drug Administration (FDA) approved use of CBD is a pharmaceutical formulation created to treat epilepsy. CBD is also under investigation for its effects on stress relief, sleep, inflammation, schizophrenia, and psychosis.

Research into THC

Unlike CBD, the FDA has not approved any therapeutic use of THC. However, other countries, including Australia and Canada, have approved the use of a pharmaceutical containing THC and CBD for multiple sclerosis.  

Outside of this pharmaceutical, the early medical evidence suggests THC could help with symptoms of pain, chemotherapy-induced nausea and vomiting, weight loss, and epilepsy. Again, none of these studies have gone all the way through to clinical trials, but these avenues offer insight into the evolution of cannabis in modern medicine.

THC to CBD: A Known Synergy

scientist investigating a cannabis bud

The effects of THC and CBD are on opposite sides of the spectrum. But if you were to try both together, you would see a beautiful blending of benefits.

A theory known as the Entourage Effect explains that when cannabinoids are used together, their individual effects are heightened or even changed. One of the most notable examples of this synergy is between THC and CBD.

As we explained, THC strongly binds to CB1 receptors. In the rare case that someone has taken too much THC, this strong connection can overwhelm the system, which may lead to discomfort. While this is a temporary experience, it is nevertheless unpleasant. 

Yet, CBD seems to have the unique ability to reduce the intensity of these side effects simply by reducing the strength of the THC-CB1 connection. Many people find products that contain a balanced blend of THC and CBD deliver a symphony of experiences but with a much lower incidence of side effects.

Our Select Spectrum collection was developed with this synergy in mind. Consider, for example, our Balance Gummies. These edibles are specifically formulated with 10 mg of delta-9 and 10 mg of CBD to create beautifully blended yet balanced effects. With every gummy, you can expect a smooth onset and a well-rounded mind-body experience. 

THC vs. CBD: Legal Status

cannabis legality judges gavel with buds

As it stands, marijuana is illegal under federal law. The government classifies any cannabis plants with over 0.3 percent THC as marijuana. 

But anything under 0.3 percent THC falls into the hemp category, which the government legalized via the 2018 Farm Bill.

The Farm Bill regulation legalized the product, sale, and consumption of hemp products. Naturally, this also legalized any cannabinoids derived from hemp, including CBD, THCa, delta-9 THC, and hexahydrocannabinol (HHC). Thanks to this 2018 legislative update, accessing hemp-derived goodies nationwide is legal. 

Just keep in mind that despite CBD's status at the national level, certain state laws have banned specific cannabinoids. We recommend checking with your state laws to ensure it's legal to order these cannabinoids where you live

Choosing the Right Product for You

With so many cannabinoids and so many different formats, where do you even begin? What cannabinoid should you start with? Should you try a gummy, flower, or something else?

The Big Decision: THC vs. CBD

Ultimately, if you've never dabbled with any hemp-derived cannabinoids, your first choice boils down to deciding between CBD vs. THC. Remember, CBD leads to mild, mellow relaxation without any psychoactive effects, while any THC (THCP, delta-8, delta-9, and the like) will lead to a range of mind-focused sensations. If you want to experience THC but are worried about the intensity, you can also try a balanced product with a 1:1 THC to CBD ratio.

The Golden Rule: Start Low and Go Slow

Whether or not you care about the differences between THC and CBD, the golden rule with anything new is to start with a small amount and increase slowly. This is especially true for any type of THC products because they do trigger more noticeable sensations than CBD. 

If you are unfamiliar with THC, always start with the lowest recommended serving size, and don't go back for more until at least three or four hours later.

Edibles vs Inhalables: The Type of Product Matters

Finally, the product type will also impact the kind of experience you can expect. When you inhale cannabis, the effects come on quickly but don't linger for more than a few hours, while edibles can take a few hours to kick in, and the effects can last all day. Check your schedule, and choose accordingly.

The Best of Both Worlds: Blending THC and CBD for a Full Spectrum of Effects

As you familiarize yourself with THC and CBD, you begin to understand their unique properties. With a slow and steady approach, you'll start to find out what it's like to sink into the euphoric glow of THC and the mellow vibes of CBD.

But we think cannabinoids are always better together, so why not explore both for a balanced and well-rounded experience tailored just for you? Experience the full spectrum of benefits with our Select Spectrum Gummies with a 2:1 or 1:1 ratio of THC to CBD.

Until next time, mind your mind.

FDA Disclaimer: The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure, or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your healthcare professional about potential interactions or other possible complications before using any product. The Federal Food, Drug, and Cosmetic Act requires this notice.

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