Both CBD and THC produce their effects via interactions with
the endocannabinoid system, or ECS. The ECS is a biological
network of receptors and chemical messengers that manage everything from pain perception to mood fluctuations to the inflammatory response.
It turns out that it's not just our own chemical messengers (called endocannabinoids) that work with this system. Scientists discovered that cannabis-derived cannabinoids also have an incredible ability to interact with the ECS due to their molecular structures.
Yet, each cannabinoid operates in a unique way, which is why there are such differences between the effects of CBD vs. THC.
Effects of THC
Let's first look at THC, and the related THC compounds like THCP, Delta-8-THC, and others. THC compounds are the only known cannabinoids that connect directly to a cannabinoid receptor called CB1. Although CB1 receptors exist throughout your body, they are highly concentrated in your brain.
Why does THC
bind to CB1? Well, THC happens to be
structurally similar to anandamide, aka the “bliss molecule.” Anandamide is a natural endocannabinoid produced by the ECS. Like a hand fitting into a glove, THC molecules fit into CB1, which leads to the powerful
effects THC is known for: euphoria, altered senses, mood uplift, and more.
Effects of CBD
Cannabidiol is the yang to THC's yin. Instead of fitting into a specific receptor, it works behind the scenes. For example, it actually
stops the breakdown of anandamide. Thus, CBD boosts their impact on both the CB1 and CB2 receptors by keeping endocannabinoids like anandamide active longer.
CBD also works on a slightly different site of the CB1 receptor, changing how other compounds like THC interact with it. This can reduce the possibility of unpleasant side effects from THC.
But other than these indirect effects, CBD doesn't develop into any truly powerful sensations. Instead, it's mellow and offers a mild, calm experience without any highs or lows.
The Benefits of THC and CBD